Guide3.3
Order of addition
Load materials in the sequence stated in the BMR. As a general rule the active ingredients are dispersed within the bulk excipients first, and the lubricant is added last. Correct sequence prevents localised concentrations of active ingredient.
| Stage | Typical materials | Notes |
|---|---|---|
| 1. Base layer | Part of the main diluent / filler | Coats the blender surface and prevents actives sticking. |
| 2. Actives | Active ingredients (pre-blended if low dose) | Sandwich between excipient layers. |
| 3. Remaining excipients | Rest of diluent, disintegrant, glidant | Glidant may be pre-sieved with part of the blend. |
| 4. Main blend | — | Blend for the validated time. |
| 5. Lubricant | Magnesium stearate | Added last, after the main blend; short, timed lubrication step. |
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