Guide10.3
Common excipients
| Excipient | Function | Typical level | Notes |
|---|---|---|---|
| Microcrystalline cellulose (MCC) | Diluent / binder | 20–90% | Highly compressible; good binding and disintegration; wet granulation and direct compression. |
| Lactose | Diluent | Up to ~80% | Increases bulk so low-dose actives can be handled and filled. |
| Povidone (PVP K30) | Binder | 2–5% | Strong wet-granulation binder; soluble in water and alcohol. |
| Croscarmellose sodium | Disintegrant | 2–5% | Helps capsules and tablets break up. |
| Colloidal silicon dioxide | Glidant | 0.1–0.5% | Improves flow; forms soft agglomerates, so usually sieved. |
| Magnesium stearate | Lubricant | 0.25–1% | Hydrophobic; add last and blend briefly; over-mixing slows dissolution. |
Typical levels are general guidance; the approved formula in the BMR always applies.
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